In this article, we will cover the top alkaloids in kratom, their effect, and their unique abilities.

Key Kratom Alkaloids and Their Effects

1. Mitragynine 

Mitragynine is a primary alkaloid found in the leaves of the Mitragyna speciosa tree, which is known as kratom. It is the most abundant alkaloid found in kratom, with approximately 60% of its total chemical content. However, the amount of mitragynine can vary based on the strain and environmental factors. 

It has a unique chemical composition that interacts with opioid receptors in the brain to provide effects such as mood enhancement, increased energy, and stress relief. Mitragynine is also responsible for sedative and stimulating effects. 

2. 7hmz

7hmz is found in minor quantities, but it is a highly potent alkaloid that makes up 0.01-0.03% of the total alkaloid content. The effect of 7hmz is stronger than that of mitragynine due to its high affinity for opioid receptors.

ON7 Hydroxy shots are a powerful punch, which is perfect for seasoned users to achieve strong and rapid effects. Manufactured by Occurs Naturally, these shots come in three effects: relief, energy, and focus, powered by strong kratom alkaloids. These shots are a new edition in the line of products by Occurs Naturally. 

3. Paynantheine

Paynantheine is another chemical compound that is widely found in kratom leaves. It has more concentration, so basically, it is the second-highest alkaloid after mitragynine. However, it is not commonly discussed as it performs little or no activity in the human body. 

4. Speciogynine

Speciogynine is also an alkaloid found in kratom that provides active effects in the human body. There is very little to no research on this, but it has the potential for more studies. 

5. Corynoxine A & B

Corynoxine A & B provides dopaminergic effects that help with focus and productivity. It also has neuroprotective potential, but studies are ongoing on this alkaloid. 

Other Notable Alkaloids

There are many more alkaloids found in kratom other than mitragynine and hydroxymitragynine, but most of them have very minimal research on them. Along with the highest found alkaloids, these smaller, concentrated alkaloids activate the simulation process in the body.

Ajmalicine is another alkaloid receptor antagonist that interacts with the human body to help stimulate and regulate various body organs. It was one of the first alkaloids found in kratom in 1970 in Southeast Asia.  

Mitraphylline is another major pentacyclic oxindole alkaloid found in kratom that has traditionally been used to deal with heart diseases, cancer, arthritis, and bone alignment. This alkaloid has more potential, but it is found in less than 1% of kratom. 

What Affects Kratom Alkaloid Content?

1. Strain & Vein Color 

Strain types such as red, white, and green all have different alkaloid profiles. Red strains are higher in 7hmz, while white vein strains are rich in mitragynine. Green vein strains have a more balanced alkaloid profile.

2. Growing Conditions 

Growing conditions, such as soil quality and climate, are highly important for alkaloid production. Tropical environments are suitable for kratom planting as the humidity in the air provides consistent alkaloids, thus producing more potent strains. These environments also have mineral-rich soil that delivers higher alkaloid content in kratom leaves. 

3. Processing Methods 

Sundrying, indoor drying, and fermentation are three common methods used to create and preserve kratom strains. Sundrying method increases 7hmz content, which is commonly used for red strains, while for white strains indoor drying method is used to preserve mitragynine alkaloid content. However, some strains, such as Gold Borneo made through a fermentation process to alter the alkaloid profile.

4. Storage Conditions

It is necessary to store alkaloids in airtight containers to longer their shelf life and preserve potency. Light and heat exposure degrade the alkaloids over time. Freezing can also increase shelf life, but it often changes the alkaloid balance. 

Most Potent Alkaloid Combinations 

You can combine Mitragynine with 7-OH for stronger relief effects. Mitragynine with Speciogynine can help you achieve balanced energy & relaxation, often found in green strains. Mitragynine combined with Paynantheine helps in muscle relaxation.

How to Identify High-Alkaloid Kratom 

You can identify high alkaloids by lab testing. Freshness also indicates good quality kratom, as bright green powder shows higher mitragynine. 

Final Thoughts

Alkaloids are present in everything we eat, drink, and use daily. They are the most commonly occurring organic compounds that are not widely discussed. Each alkaloid has its own set of characteristics, pros and cons, effects, and uses, so it has a specific name rather than being known as an alkaloid in general. Kratom Alkaloids are one of the commonly searched keywords by people who are looking to find the nitty-gritty of kratom before consumption.

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The post Comprehensive Guide To Kratom Alkaloids and Properties appeared first on Occurs Naturally.

Despite being from the same category, each has certain individual characteristics. Both of them provide potent relaxation and pain-relieving properties.

This article will shed light on the comparison of both kratom strains.

Red Borneo vs. Red Bali Kratom: What’s the Difference?

Here is a detailed breakdown of the differences between Red Borneo and Red Bali Kratom. 

Origins and Growing Conditions

Red Borneo Kratom

Found in the island of Borneo which is one of the largest islands in Southeast Asia. The atmosphere is dense with more humid rainforest and mineral-rich soil. 

Red Bali Kratom

Red Bali Kratom is found in Bali, Indonesia. It is now grown in other parts of Southeast Asia also, especially in the mainland. The tropical climate of Bali contributes to the strong and potent alkaloid properties of kratom and it also plays a huge role in growing high-quality kratom leaves.

Alkaloid Profile and Composition

Red Borneo Kratom

Red Borneo Kratom has a higher concentration, which gives it strong, stimulating, and sedative qualities. It contains greater levels of mitraphylline and speciogynine, which contribute to providing calming and muscle-relaxing effects. 

The chemical composition of red Borneo makes it a suitable choice for managing chronic pain and anxiety; it provides a calming effect without overpowering sedation and side effects.

Red Bali Kratom

Red Bali Kratom is a mix of mitragynine and other alkaloids. However, the concentration of mitragynine is higher than that of other types of kratom, especially red Borneo. The higher content of mitragynine is responsible for relieving pain while offering energy, focus, and relaxation. This type is more suitable for managing stress and mild to moderate pain while maintaining a sense of clarity.

Effects and Benefits of Red Borneo and Red Bali Kratom

Red Borneo provides potent effects due to its analgesic properties. It is highly effective for relieving chronic pain, joint pain, and muscle soreness.

It is also popular for its calming effects. Red Borneo is suitable for use in the evening or during stressful times. 

Due to its balanced alkaloid profile, is magically leaves your mood, providing mild Euphoria, and works on your mental health. 

The sedative effects are mild, but they can help with sleep quality, especially for people who suffer from insomnia or restless nights. 

On the other hand, Red Bali is known for its analgesic properties which are slightly less than red Borneo. It is suitable for mild to moderate pain relief. The alkaloid profile found in this type of kratom is best for both relaxing and achieving energy affects. Depending on the dosage, it is flexible for intake in both daytime and evening use. 

Unlike Red Borneo, it is used to achieve mild Euphoria making it an ideal choice for managing stress, anxiety disorders, low motivation, and bad mood. 

Dosage Recommendations

Finding the right dosage of red-Borneo kratom is necessary for achieving the desired results. Low dosage which is usually (1 to 2 grams) is best for mild relaxation and stress relief. Moderate doors (3 to 5 grams) help in managing anxiety and moderate pain relief. A high dose (6 to 8 grams) is appropriate for deep relaxation and sleep support.

Red Bali kratom dosage recommendation is pretty similar to Red Borneo. Low doses provide mild energy and relaxation, however, high doses will cause deep relaxation, stronger pain relief, and more sedation. 

Side Effects and Precautions

Red Borneo kratom can cause nausea, dizziness, and constipation in higher doses. People who are sensitive to strong sedatives must use them in low doses. Excessive use of kratom can lead to drowsiness and mind fog. 

Red Bali kratom side effects such as headaches, nausea, or dry mouth are expected in higher dosage intake. If taken in large amounts it can cause light jitters. It is recommended to use it intermittently to avoid dependence. 

Which Kratom Should You Choose: Red Borneo vs Red Bali?

Red Borneo kratom can prefer sedative effects that will help you calm down and sleep better without overwhelming sedation, red Borneo should be your optimal choice. 

It is best for chronic pain, anxiety management, or sleep issues.

If you are looking for versatile kratom strains that can help you achieve relaxation and provide you with mild energy, red Bali kratom is one of the best kratom strains. 

You can have it in both daytime and nighttime without feeling drowsy. It is best for pain relief during the day. 

Where to find the best kratom tablets for pain relief?

Occurs Naturally offers the best quality kratom tablets. At OccursNaturally, we use rigorously tested ingredients and produce our kratom tablets with stringent quality controls. They are safe, effective, and natural alternatives for stress relief, energy enhancement, and cognitive support. 

To unwind, rejuvenate, and embrace tranquility, try our relief tablets. These tablets are formulated with Mitragynine pseudoindoxyl, an active metabolite. 

It’s also known for its relaxing effects. They are perfect for unwinding after a long day, reducing stress, and promoting a sense of tranquility.

Conclusion

Both red Borneo and red Bali kratom offer unique benefits such as pain relief, relaxation, or mode enhancement. Red Borneo is better for those seeking deep relaxation and more intense pain relief, however, red Bali is best for energizing effects, depending on the dose. 

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The post Red Borneo vs Red Bali: What’s the Difference? appeared first on Occurs Naturally.

This article will discuss Mitragynine Pseudoindoxyl, its chemical structure and origin, its benefits, uses, and more. 

Introduction to Mitragynine Pseudoindoxyl

Mitragynine Pseudoindoxyl is the sole compound that has gathered interest for its potential therapeutic properties which are helping people deal with pain management and opioid receptor interactions without any side effects. As compared to conventional opioids, this is used to revolutionize pain treatments offering the best alternative for people with chronic pain while mitigating risks like respiratory depression or addiction. 

Chemical Structure and Origin of Mitragynine Pseudoindoxyl

Mitragynine Pseudoindoxyl is commonly produced by modifying mitragynine in labs. It is a kind of semi-synthetic derivative of mitragynine. The chemical structure is distinct because, unlike most opioids, it does not have the ability to bind in typical bond settings. The unique Bond structure is responsible for these potential effects such as pain relief and it also reduces the risk of side effects like respiratory issues.

The chemical transformation of mitragynine into Mitragynine Pseudoindoxyl involves a conversion process that changes its indole ring which makes it more effective in providing certain types of opioid receptors without eliciting the euphoria effects that often lead to misuse.  

Mechanism of Action

Mitragynine Pseudoindoxyl interacts with (MOR) mu-opioid receptors and delta opioid receptors (DOR) in the human brain, similar to traditional opioids. Here are some mechanisms of action that MPs produce. 

Biased Agonism

Unlike other opioids, Mitragynine Pseudoindoxyl only activates certain parts of the human brain; it does not work with all opioid receptors which leads to pain relief along with respiratory depression. This phenomenon is called Biased Agonism as it allows only effective pain relief with no harmful side effects which are often associated with opioids. 

G-Protein Pathway Activation

Mitragynine Pseudoindoxyl is known to activate the G-protein pathway over the beta-arrestin pathway at the mu-opioid receptor. Its activation often provides effective pain relief without adverse effects, such as constipation and mental confusion. By focusing on the G-protein pathway, Mitragynine Pseudoindoxyl offers therapeutic benefits without some of the downsides of conventional opioids. 

Potential Benefits of Mitragynine Pseudoindoxyl

• Pain Management: It is one of the primary benefits of Mitragynine Pseudoindoxyl. It has a potent analgesic effect that relieves pain in the human body. It is used as an alternative treatment for people dealing with chronic pain conditions who are unable to use traditional opioids due to their side effects.
• Reduced Risk of Respiratory: Respiratory issues such as slow breathing are one of the most common side effects of opioid use. Several opioid overdose deaths have been reported in recent years. However, Mitragynine Pseudoindoxyl has a unique mechanism that reduces this risk, as it does not interact with the respiratory system, making it a safer option for pain relief. 
• Lower Risk of Dependence: Studies have shown opioid dependence with traditional painkillers, but Mitragynine Pseudoindoxyl may be less habit-forming as it involves distinct receptors that interact with the human body and leaves less euphoria which potentially lessens the chance for misuse.
• Anti-inflammatory Properties: Some research also indicates that Mitragynine Pseudoindoxyl has anti-inflammatory effects further helping in pain management.
• Enhanced Tolerance Profile: Many patients on traditional opioids move to higher dosages to achieve the same stimulating effect or pain relief, known as tolerance. Mitragynine Pseudoindoxyl has unique properties that may help reduce the rate at which tolerance develops so you can use it for long-term pain management even with low dosage. 

Applications and Current Research of Mitragynine Pseudoindoxyl

There needs to be more research on Mitragynine Pseudoindoxyl. It’s still in the early stages. Mitragynine Pseudoindoxyl has amazing characteristics that have gathered the interest of people in the pharmacology field. Studies have primarily focused on its potential as a safer, non-addictive alternative to conventional opioids.

Chronic Pain Treatment

Mitragynine Pseudoindoxyl could be beneficial for individuals who suffer from chronic pain, including conditions like arthritis, fibromyalgia, and neuropathic pain.

Opioid Alternative

For post-surgical pain and other acute pain scenarios, Mitragynine Pseudoindoxyl provides lots of benefits and acts as a safe alternative to opioids due to its unique properties. 

Safety and Precautions of Mitragynine Pseudoindoxyl

• Limited Human Studies: Mitragynine Pseudoindoxyl studies are limited to animal models and labs, so human trials are still needed to better understand its effects, safety, and efficiency. 
• Dosage and Administration: Mitragynine Pseudoindoxyl is not available in the markets as a pharmaceutical product so appropriate dosage and formulation are still under investigation by concerned departments.
• Interactions with Other Substances: Painkillers, antidepressants, and other substances that control the central nervous system can interact with opioid receptors such as Mitragynine Pseudoindoxyl.
• Potential Legal and Regulatory Issues: The legal status of Mitragynine Pseudoindoxyl is uncertain in many states and countries. 

Discover Natural Relief with ON7 Mitragynine Pseudoindoxyl Relief Tablets

You can now experience the relief you have been searching for a long time with ON7 Relief tablets, featuring premium kratom mitragynine pseudoindoxyl. The robust formula harnesses the unique characteristics of mitragynine pseudoindoxyl, a compound that is known for its effective pain relief qualities and has minimal side effects as compared to regular opioids. 

Why Choose Occurs Naturally Relief Tablets?

1. Natural Ingredients: ON7 Tablets contain high-quality ingredients, naturally sourced from kratom, ensuring the users get the best results.
2. Effective Pain Management and Stress Relief: Mitragynine pseudoindoxyl is recognized for its analgesic effects which makes it a good choice for users seeking relief from pain and stress. 
3. Convenient to Use: ON7 pressed tablets are easy to take anywhere. 

Don’t let the stress and pain hold you back for long. Try ON7 Relief tablets today, and discover a natural pain relief alternative. 

Conclusion

As mitragynine pseudoindoxyl helps in pain management for many users, it stands out as a potential area for future research and clinical application. Its distinct pharmacological characteristics could lead to safer and effective analgesic development, which can help patients who are looking for relief from chronic pain without conventional opioids that are riskier. 

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The post What is Mitragynine Pseudoindoxyl? A Comprehensive Guide appeared first on Occurs Naturally.