In this article, we will cover the top alkaloids in kratom, their effect, and their unique abilities.

Key Kratom Alkaloids and Their Effects

1. Mitragynine 

Mitragynine is a primary alkaloid found in the leaves of the Mitragyna speciosa tree, which is known as kratom. It is the most abundant alkaloid found in kratom, with approximately 60% of its total chemical content. However, the amount of mitragynine can vary based on the strain and environmental factors. 

It has a unique chemical composition that interacts with opioid receptors in the brain to provide effects such as mood enhancement, increased energy, and stress relief. Mitragynine is also responsible for sedative and stimulating effects. 

2. 7hmz

7hmz is found in minor quantities, but it is a highly potent alkaloid that makes up 0.01-0.03% of the total alkaloid content. The effect of 7hmz is stronger than that of mitragynine due to its high affinity for opioid receptors.

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3. Paynantheine

Paynantheine is another chemical compound that is widely found in kratom leaves. It has more concentration, so basically, it is the second-highest alkaloid after mitragynine. However, it is not commonly discussed as it performs little or no activity in the human body. 

4. Speciogynine

Speciogynine is also an alkaloid found in kratom that provides active effects in the human body. There is very little to no research on this, but it has the potential for more studies. 

5. Corynoxine A & B

Corynoxine A & B provides dopaminergic effects that help with focus and productivity. It also has neuroprotective potential, but studies are ongoing on this alkaloid. 

Other Notable Alkaloids

There are many more alkaloids found in kratom other than mitragynine and hydroxymitragynine, but most of them have very minimal research on them. Along with the highest found alkaloids, these smaller, concentrated alkaloids activate the simulation process in the body.

Ajmalicine is another alkaloid receptor antagonist that interacts with the human body to help stimulate and regulate various body organs. It was one of the first alkaloids found in kratom in 1970 in Southeast Asia.  

Mitraphylline is another major pentacyclic oxindole alkaloid found in kratom that has traditionally been used to deal with heart diseases, cancer, arthritis, and bone alignment. This alkaloid has more potential, but it is found in less than 1% of kratom. 

What Affects Kratom Alkaloid Content?

1. Strain & Vein Color 

Strain types such as red, white, and green all have different alkaloid profiles. Red strains are higher in 7hmz, while white vein strains are rich in mitragynine. Green vein strains have a more balanced alkaloid profile.

2. Growing Conditions 

Growing conditions, such as soil quality and climate, are highly important for alkaloid production. Tropical environments are suitable for kratom planting as the humidity in the air provides consistent alkaloids, thus producing more potent strains. These environments also have mineral-rich soil that delivers higher alkaloid content in kratom leaves. 

3. Processing Methods 

Sundrying, indoor drying, and fermentation are three common methods used to create and preserve kratom strains. Sundrying method increases 7hmz content, which is commonly used for red strains, while for white strains indoor drying method is used to preserve mitragynine alkaloid content. However, some strains, such as Gold Borneo made through a fermentation process to alter the alkaloid profile.

4. Storage Conditions

It is necessary to store alkaloids in airtight containers to longer their shelf life and preserve potency. Light and heat exposure degrade the alkaloids over time. Freezing can also increase shelf life, but it often changes the alkaloid balance. 

Most Potent Alkaloid Combinations 

You can combine Mitragynine with 7-OH for stronger relief effects. Mitragynine with Speciogynine can help you achieve balanced energy & relaxation, often found in green strains. Mitragynine combined with Paynantheine helps in muscle relaxation.

How to Identify High-Alkaloid Kratom 

You can identify high alkaloids by lab testing. Freshness also indicates good quality kratom, as bright green powder shows higher mitragynine. 

Final Thoughts

Alkaloids are present in everything we eat, drink, and use daily. They are the most commonly occurring organic compounds that are not widely discussed. Each alkaloid has its own set of characteristics, pros and cons, effects, and uses, so it has a specific name rather than being known as an alkaloid in general. Kratom Alkaloids are one of the commonly searched keywords by people who are looking to find the nitty-gritty of kratom before consumption.

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The post Comprehensive Guide To Kratom Alkaloids and Properties appeared first on Occurs Naturally.

In Thailand, the Mitragyna speciosa tree and leaf preparations are called kratom. Traditionally, fresh or dried kratom leaves are chewed or made into tea; they are seldom smoked. 

The low dose of kratom gives it a stimulating effect, and this is taken during long hours of work. At high dosages, however, it can have sedative-narcotic effects. It is also used in traditional medicine and as an opium substitute. 

Some of the phytochemicals include 40 structurally related alkaloids, flavonoids, terpenoid saponins, polyphenols, and different glycosides, among others. The main psychoactive components in the leaves are mitragynine and other alkaloids, both found only in Mitragyna speciosa.

What is Mitragynine?

Mitragynine is a chemical compound found in the leaves of the Mitragyna speciosa tree, known as kratom. This native to Southeast Asia is mainly grown in Thailand, Indonesia, and Malaysia. Asians have used this for centuries to boost energy, improve focus, and relieve muscle pain. 

This alkaloid is in the percentage of 60% of the total alkaloid compounds of kratom, which makes it the most dominant. However, the amount of mitragynine can vary based on the strain and environmental factors. 

This is due to Mitragynine having the ability to bind with opioid receptors in one’s brain, leading to several effects that many people who use the substance report feeling, including exhilaration, energy boosts, and pain-killing influence. This component is also responsible for sedative and stimulating effects. 

However, it is very different from traditional opioids and does not carry the same level of addiction risk, which is why it’s safe to use.

Chemistry Of Mitragyna Speciosa

Molecular structure: Mitragynine 

Among the alkaloids present in the leaves, mitragynine ranks highest in terms of its content. It was first isolated as a crystalline substance in 1921, and the nature of the chemical combination of its constituent elements was not determined until 1964. 

Mitragynine hardly dissolves in water but dissolves well in ordinary organic solvents such as acetone, acetic acid, alcohols, chloroform, and Diethyl ether to form fluorescent solutions. Mitragynine distils at 230–240 °C at 5 mmHg. It forms white, amorphous crystals that melt at 102–106 °C. The melting point of mitragynine hydrochloric acid salt is 243°C; the picrate melts at 223–224 °C, and the acetate at 142 °C.

• Molecular formula: C23H30N2O4
• Molecular weight: 398.50 g/mol

Molecular structure: 7-hm

7-hm was found in samples of kratom leaves in 1993, and its levels are greatly inferior to the amounts of mitragynine. 

The chemical total syntheses reported for several kratom alkaloids are too complex to be used for the economic production of any of these compounds. However, mitragynine can serve as a chemical precursor to the more potent 7-hm.

• Molecular formula: C23H30N2O5
• Molecular weight: 414.50 g/mol

Mitragyna Speciosa Uses

Kratom can be consumed by using raw or dried leaves, chewing them, or soaking them in water to make tea. When making tea, lemon juice is often added to facilitate the extraction of plant alkaloids; before drinking, sugar or honey may be added to mask the bitter taste of the brew. These dried leaves can even be smoked when required.

For strength and merriment, common ‘kratom eaters’ take one to three fresh leaves at any one time. The veins are usually eaten separately from the leaves or eaten with the leaves, and sometimes salt is added to prevent constipation. Only the masticated material is swallowed. Consumption is followed by drinking warm water or coffee, tea, or palm sugar syrup. 

Regular and addicted users chew 3 to 10 times a day. When kratom is not available, the leaves of Mitragyna javanica (another known as Mitragyna parvifolia) are used as a substitute.

In southern Thailand, in the last few years, homemade ice-cold cocktail drinks ‘4×100’ have been circulated among the young Muslim population because they contain alcohol substitutes. 

Medical Use Of Mitragyna Speciosa 

Though six Asian and four African Mitragyna species are reported to be used in traditional medicine, the sedative, narcotic, and psychoactive effects are unique for Mitragyna speciosa only. In Southeast Asia, kratom is used as an antidiarrheal, a cough suppressant, an antidiabetic, an intestinal deworming agent, and a wound poultice, as well as to wean addicts off heroin. 

In other continents, there are anecdotal reports of kratom preparations being used to self-treat Chronic pain and opioid withdrawal syndrome and as a replacement for opioid analgesics. 

There is, however, no approved use of kratom or its alkaloids in modern medicine. It has been suggested that the therapeutic potential of kratom or its purified ingredients for the treatment of pain, depression, and drug withdrawal symptoms should be explored.

Benefits of Mitragynine

Its potential benefits for the human body and mind make it a key reason for people choosing kratom over pharmaceutical pain relievers.

Below are some key benefits of mitragynine based on consumer reviews and preliminary research: 

1. Pain Relief

Pain relief is one of the top benefits of mitragynine. It can interact with opioid receptors, making it helpful for people dealing with chronic pain conditions such as arthritis, fibromyalgia, and migraines. Research has shown that this component has an analgesic effect, which is very useful for people seeking natural pain relief.

Related:

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2. Mood Enhancement

Another great benefit of consuming this herb is its potential to improve mood and reduce symptoms of anxiety. It can enhance mood by triggering the release of endorphins and serotonin. Kratom consumption allows users to feel a sense of calm, well-being, and optimism, which is primarily due to mitragynine. 

3. Increased Energy and Focus

Mitragynine also acts as a stimulant, which helps in energy boost and focus. People who are looking for natural alternatives to coffee or other caffeine drinks often opt for kratom.  Farmers and laborers in Southeast Asia are using this herb to combat fatigue and increase productivity. They usually chewed the leaves directly torn from the tree. 

4. Reduced Dependency Risk

As compared to traditional opioids, which are synthetic-based, this component has a lower risk of dependency which makes it a good option for those seeking natural relief without the addictive potential associated with pharmaceutical painkillers. However, some users consume it in high doses which can lead to dependency over time. The amount of dosage consumed is highly important in kratom intake. 

Effects of Mitragynine

The effects of mitragynine are dose-dependent, which means you can experience different effects based on the amount consumed. Different dose levels affect the body from different angles.

1. Low Doses (1-5 grams): 

At low doses, it provides stimulating effects which include alertness, energy, and focus. However, these effects will last only a few hours. Low dose is consumed as a natural alternative to caffeine, as it gives alertness and an energy boost without the jittery side effect

2. Moderate Doses (5-10 grams):

If used in an adequate amount, it creates a balance between stimulation and relaxation. Some people also feel a sense of calm with a moderate level of pain relief. People who are looking to alleviate pain or reduce stress while remaining functional throughout the day can use this in moderate amounts. 

3. High Dose (10+ grams): 

If consumed in higher amounts, it can provide sedative effects resulting in deep relaxation and sometimes drowsiness. High dose intake is risky and can be fatal. Several side effects might appear, such as nausea, vomiting, diarrhea, and other respiratory issues. 

Only people dealing with insomnia can have high doses, but under supervision. If you have any underlying health conditions, do consult with your healthcare provider before using mitragynine. 

Safety and Regulation

Despite its widespread use, Mitragyna speciosa remains controversial in many parts of the world. The plant’s effects and potential risks have prompted regulatory scrutiny, with some countries banning its use entirely. In other regions, such as the United States and parts of Europe, kratom is sold legally but often with warnings and restrictions.

Potential Risks:

• Dependency and Withdrawal: Regular use of high doses can lead to dependency, and some users report withdrawal symptoms upon cessation.
• Side Effects: Common side effects include nausea, dizziness, constipation, and dry mouth. In rare cases, more severe reactions may occur, especially when combined with other substances.

Final Thoughts

Mitragyna speciosa is a fascinating and complex plant with a rich history and a wide range of applications. While its potential benefits have captivated users and researchers alike, it is crucial to approach its use with caution and informed decision-making.

Understanding the plant’s properties, effects, and limitations can help individuals make choices that align with their needs and values.

Whether you are exploring Mitragyna speciosa as a botanical curiosity, a potential wellness aid, or a subject of academic interest, its story serves as a reminder of the intricate relationships between humans and the natural world. 

By respecting the plant and the cultures from which it originates, we can continue to learn from and responsibly utilize its remarkable properties.

Discover the best quality mitragynine tablets at Occurs Naturally, where you can enjoy a concentrated dose of this powerful alkaloid. 

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• 9 Best Kratom Tablet Brands For Energy

The post What Is Mitragyna Speciosa? appeared first on Occurs Naturally.

However, there is another plant known as Mitragyna javanica which is often mentioned alongside kratom. They belong to the same genus but have important distinctions that affect their unique benefits. 

In this article, we will explore the relationship between kratom and Mitragyna javanica and explore their differences, similarities, and potential benefits.

What is Mitragyna Javanica?

Mitragyna javanica is not very popular in the mitragyna genus family which is the same as kratom. Both are native to Southeast Asia and are mainly grown in regions such as Thailand, Malaysia, and Indonesia. It has been used in traditional practices but did not gain the same level of attention as kratom. 

It is also known as “javanica” due to its connection to the island of Java, but its use is not as widespread as kratom. Unlike kratom, Mitragyna javanica does not have the same alkaloid composition. 

The effects of Mitragyna javanica are less strong than those of kratom, both in terms of potency and benefits. While Mitragyna javanica is related to kratom in botanical terms, the pharmacological effects have not been studied and understood yet.  

The Alkaloid Composition: Key Differences 

Kratom is known mainly for its alkaloid profile. The two alkaloids mitragynine and 7 hydroxymitragynine are responsible for the stimulating and sedating effect of kratom on the human body and mind. The alkaloids in kratom react with opioid receptors in the human brain providing analgesic properties.

In contrast, Mitragyna javanica contains a different set of alkaloids with fewer potent alkaloids found in kratom. They are less likely to contribute to achieving the same intensity of effects. Mitragyna javanica may have a milder stimulating effect but can provide the same level of pain relief, or mood enhancement.

Differences in Effects

The effect of kratom is often appreciated by consumers, who are looking for pain relief, energy boost, or enhanced focus. Kratom strains can vary in different color (red, white, green) potency, and benefits. Some users also report feelings of euphoria and sedation while others experience more active effects like improved energy. 

On the other hand, Mitragyna javanica is completely different in effects. It may offer mood-lifting properties, however, its primary benefits are not as clear as kratom. As it does not have much research back studies, we can only rely on user experience and reviews. Some people have reported that Mitragyna javanica does not provide the same level of stimulation or analgesic effects.

Potential Benefits of Kratom and Mitragyna Javanica

Let’s now look at the benefits of both kratom and mitragyna javanica:

Kratom’s Benefits 

• Kratom is commonly known as a natural painkiller due to its opioid-like effects. It often helps people manage chronic pains or discomfort.
• Certain strains of kratom like white and green are known for uplifting energy and increasing alertness. 
• It is also commonly known for mood-lifting qualities. People have been using it for centuries to help reduce anxiety, stress, and depression. 

Mitragyna Javanica’s Benefits

• Mitragyna javanica provides mild pain-relieving benefits. 
• It is also known to have mild mood-lifting properties but is less effective than kratom. 
• Some people have also reported a gentle energy left with Mitragyna javanica but it does not provide the same level of alertness or focus. 
• In comparison to kratom, Mitragyna javanica provides more relaxing effects which can help in reducing anxiety.

How Are Kratom and Mitragyna Javanica Used?

As both plants are related to Southeast Asia there’s a common trend of using herbs in the form of powders and brewed tea. Both Mitragyna javanica and Kratom are traditionally consumed in the form of dried leaves, powder, capsules, and extracts. 

As the popularity of kratom has become more widespread than Mitragyna javanica, the consumption ways are also extended. All around the world people are using it in tablet form, liquid shots, mixed into beverages, or capsules for easy ingestion. In traditional settings, people also like to chew the leaves directly which might be bitter for some consumers.

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Legal Status and Availability 

The legality of kratom varies around the world and within countries. In the United States, kratom is legal in many states but there are some regulations due to safety concerns or potential misuse. 

On the other hand, Mitragyna javanica is less regulated because it is not as popular as kratom. While kratom has been used in countries like Thailand, Malaysia, and Indonesia, Mitragyna javanica is lesser known and its use is more localized in certain regions of Southeast Asia.

Can They Be Used Together?

Mitragyna javanica and kratom are related plants, but they have different purposes and benefits. Some people might like to combine the two, but the effects can be dangerous as combining both plants will heighten the alkaloid content and affect the central nervous system. It is important to approach their combined use with caution, especially for those unfamiliar with their effects. 

Conclusion: The Connection Between Kratom and Mitragyna Javanica

While Mitragyna javanica and kratom are both members of the same family and share a botanical connection, however there effects are different. They have some similarities like geographic origin as both belong to Southeast Asia but have different alkaloid profiles. 

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The post Kratom and Mitragyna Javanica: How They Are Related? appeared first on Occurs Naturally.

Mitragynine holds properties that contribute to the herb’s diverse effects and benefits. Understanding this component will help us determine if this herb will help them achieve their fitness and wellness goals. This article will explore mitragynine, its benefits, and its effects on the human body and mind. 

What is Mitragynine?

Mitragynine is a chemical compound found in the leaves of the Mitragyna speciosa tree, which is known as kratom. This native to Southeast Asia is mainly grown in Thailand, Indonesia, and Malaysia. Asians have used this for centuries to boost energy, improve focus, and relieve muscle pain. 

Mitragynine is the most abundant alkaloid found in kratom which is approximately 60% of its total chemical content. However, the amount of mitragynine can vary based on the strain and environmental factors. 

Mitragynine has a unique chemical structure that allows it to interact with opioid receptors in the brain which is responsible for many effects that users report, such as mood enhancement, increased energy, and pain relief. This component is also responsible for sedative and stimulating effects. 

However, it is very different from traditional opioids and does not carry the same level of addiction risk that is why it’s safe to use. 

Benefits of Mitragynine

Its potential benefits for the human body and mind make it a key reason for people choosing kratom over pharmaceutical pain relievers.

Below are some key benefits of mitragynine based on consumer reviews and preliminary research: 

1. Pain Relief

Pain relief is one of the top benefits of mitragynine. It can interact with opioid receptors, making it helpful for people dealing with chronic pain conditions such as arthritis, fibromyalgia, and migraines. Research has shown that this component has an analgesic effect which is very useful for people seeking natural pain relief. 

2. Mood Enhancement

Another great benefit of consuming this herb is its potential to improve mood and reduce symptoms of anxiety. It can enhance mood by triggering the release of endorphins and serotonin. Kratom consumption allows users to feel a sense of calm, well-being, and optimism which is primarily due to mitragynine. 

3. Increased Energy and Focus

Mitragynine also acts as a stimulant which helps in energy boost and focus. People who are looking for natural alternatives to coffee or other caffeine drinks often opt for kratom. Farmers and laborers in Southeast Asia are using this herb to combat fatigue and increase productivity. They usually chewed the leaves directly torn from the tree. 

4. Reduced Dependency Risk

As compared to traditional opioids which are synthetic-based based this component has a lower risk of dependency which makes it a good option for those seeking natural relief without the addictive potential associated with pharmaceutical painkillers. However, some users consume it in high doses which can lead to dependency over time. The amount of dosage consumed is highly important in kratom intake. 

Effects of Mitragynine

The effects of mitragynine are dose-dependent which means you can experience different effects based on the amount consumed. Different dose levels affect the body from different angles.

1. Low Doses (1-5 grams): 

At low doses, it provides stimulating effects which include alertness, energy, and focus. However, these effects will last only a few hours. Low dose is consumed as a natural alternative to caffeine as it gives alertness and an energy boost without the jittery side effect

2. Moderate Doses (5-10 grams):

If used in an adequate amount, it creates a balance between stimulation and relaxation. Some people also feel a sense of calm with a moderate level of pain relief. People who are looking to alleviate pain or reduce stress while remaining functional throughout the day can use this in moderate amounts. 

3. High Dose (10+ grams): 

If consumed in higher amounts, it can provide sedative effects, resulting in deep relaxation and sometimes drowsiness. High dose intake is risky and can be fatal. Several side effects might appear, such as nausea, vomiting, diarrhea, and other respiratory issues. Only people dealing with insomnia can have high doses, but under supervision. If you have any underlying health conditions, consult with your healthcare provider before using mitragynine. 

Note: Learn more about Kratom’s detailed dosage guidelines

One of the unique characteristics of mitragynine is that it provides relaxation and stimulation both at the same time, depending on the dose and the type of strain. We recommend you start with a low dose and gradually move to a moderate amount, especially if you are new to any kind of herbal intake. 

The effect of mitragynine can also vary based on the type of kratom strain, as green Maeng Da and white vein kratom are the most stimulating, and red vein kratom offers more sedative and stronger effects. 

The Importance of Quality in Mitragynine Effects 

The quality of kratom highly affects the efficiency of mitragynine. Low-quality mitragynine often has less alkaloid content and potency, leading to inconsistent or weak effects. When purchasing high-quality kratom, you need to ensure that the product contains a reliable mitragynine level and provides the desired benefits. If you want a good-quality product, you need to check the lab results, which are essential for checking mitragynine concentration.

Mitragynine is available in various forms in the market and online. You can get the best quality mitragynine tablets at Occurs Naturally. They provide a concentrated dose of this powerful alkaloid. It offers 3 different experiences for (Relief, Energy, and Focus). These tablets give more potent and targeted effects compared to traditional kratom products, so you can enjoy potential benefits sooner and with greater intensity.

Conclusion

Mitragynine is a unique alkaloid found in kratom, which is effective for pain relief and mood enhancement. However, it is dependent on the amount consumed, but users must approach it with caution and awareness of the potential side effects and risks. 

For high-quality kratom and responsible use, you need to know the full benefits and safety guidelines of mitragynine. As kratom’s popularity continues to rise, mitragynine is the focal point of discussion and research among scientists and consumers. 

There are fewer studies on mitragynine; however, responsible use is essential for a safe and effective experience with this unique alkaloid. 

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The post Mitragynine: An Important Kratom Alkaloid appeared first on Occurs Naturally.