7-Hydroxymitragynine (7-OH) is a terpenoid indole alkaloid found in the plant Mitragyna speciosa, commonly known as kratom.
First identified in 1994, it is a natural derivative of mitragynine, which is present in kratom leaves. Like mitragynine, 7-OH binds to opioid receptors, but studies indicate that 7-OH has a significantly higher binding potency.
In this guide to 7-Hydroxymitragynine, we will explain its formulation, common effects, conversion, list of products, and more.
What is 7-OH Mitragynine? – Kratom Active Ingredient
Molecular formula: C23H30N2O5
Molecular weight: 414.50 g/mol
7-Hydroxymitragynine is present in kratom but in very minor amounts. It was identified in 1994 and found to be an active metabolite of mitragynine. Hydroxymitragynine is the kratom plant’s principal psychoactive alkaloid.
It plays an important part in enhancing mitragynine’s pain-relieving effects by stimulating opioid receptors. Hydroxymitragynine has more power than morphine to deal with pain. Apart from opioid receptors, 7-Hydroxymitragynine can pose a stronger impact on your dopamine, serotonin, and adrenergic receptors.
What are the Common Effects of 7-Hydroxymitragynine?
7-Hydroxymitragynine has multiple effects due to its opioid-like properties. It is known to reduce pain, improve mood, and provide stimulating effects.
Here are some common effects of 7-Hydroxymitragynine:
- Euphoria and Sedation: Kratom extract which contains 7-hydroxymitragynine produces euphoria and sedation.
- Addiction: 7-Hydroxymitragynine in whole kratom leaves can cause milder withdrawal symptoms and a lower risk of developing addiction while concentrated and pure 7-O can cause addiction, tolerance, and withdrawal symptoms.
- Pain Relief: 7-Hydroxymitragynine is 13 times more strong than morphine. It is also known for its analgesic effects that helps in pain relief by working on mu-opioid receptors.
- Opioid Withdrawal: 7-Hydroxymitragynine helps individuals reduce opioid withdrawal and also aids in releasing withdrawal symptoms.
How to Convert Kratom’s Mitragynine to 7-Hydroxymitragynine?
Kratom’s mitragynine is converted to 7-hydroxymitragynine through a natural biochemical process that occurs in your body. Usually after ingestion, your metabolism breaks mitragynine and converts it into 7-hydroxymitragynine.
Sometimes this conversion also happens inside the laboratory where enzymes are used to introduce the hydroxy group at the 7-position of mytragynine. Common enzymes that are being used are cytochrome P450 (CYP) isoforms.
Where to get 7-OH Mitragynine Products?
7-OH products are easily found in the market in the form of extracts or tablets. You can get the best quality 7-hydroxymitragynine tablets at Occurs Naturally. They provide a concentrated dose of this powerful alkaloid.
They offer 3 types of 7-OH tablets (Relax, Energy, and Focus), with 20mg per tablet in a pack of 6 servings. These tablets give more potent and targeted effects compared to traditional kratom products, so you can enjoy potential benefits sooner and with greater intensity.
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Focus 3 Count BOX$198.00 -
Energy 3 Count BOX$198.00
7-Hydroxymitragynine Rules and Regulations
The FDA has not approved kratom buying and selling and considers it a “Drug of Concern”. Some states have banned it completely while others have an age limit of 21 years.
Banned in states:
- Alabama
- Arkansas
- Indiana
- Rhode Island
- Vermont
- Wisconsin
Other states regulate their sale with varying guidelines, such as:
- Age restrictions
- Marketing limitations for children
- Standards for adulteration and contamination prevention
- Labeling requirements for consumer transparency
- Testing and sampling protocols to ensure product safety
- Registration and permitting processes for sellers
- Regulation of synthetic alkaloids
- Local authority provisions for enforcement
- Private rights of action for legal recourse
- Taxation policies applicable to sales
Potential Addiction Risks & Side Effects
7-hydroxymitragynine has several side effects, and that’s why it is controversial among authorities. People who are using it claim that it is risk-free and a viable alternative to opioids however, if taken in higher dosage it can cause severe damage to the lungs and liver.
Research indicates that high doses of hydroxymitragynine provide adverse effects, instead of providing pleasurable or relaxing sensations, it leaves aversive and unpleasant effects on your brain.
Kratom has some serious side effects if not used properly, in a limited dosage. It can cause nausea and vomiting, constipation, and dry mouth. If used without guidance and on higher doses, it can lead to more severe issues like liver dysfunction, high blood pressure, loss of breath, and confusion in mind. To a serious extent, it can cause tremors and even seizures.
Early studies have found kratom as an antidepressant and hunger suppressant. Another study performed on rats has concluded that Kratom supplementation may reduce hunger by affecting the hypothalamus, the brain region that regulates appetite and cravings. However, further research is necessary to determine whether these effects occur in humans.
Another animal study found that kratom reduced corticosterone levels in mice. Elevated corticosterone is one of the brain chemical changes commonly associated with depression.
Conclusion
7-hydroxymitragynine is good for pain relief and has a more potent effect than morphine, almost 13 times. If used in milder dosage, it can provide several benefits for the human body. People in Southeast Asia use it to achieve relaxation and improve their energy levels.
Dosage is critical in the consumption of 7-hydroxymitragynine as higher dosage can lead to dependency and addiction. Occurs Naturally provides 7-hydroxymitragynine tablets with precise dosages that are safe and effective. Check how you can integrate these tablets into your daily routine.
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