7-hydroxy or 7-OH is one of the most potent alkaloids found in kratom. It has strong pain-relieving and sedative properties. Comes next to mitragynine, this alkaloid is more powerful, up to 30x in effects on opioid receptors.
In this article, we will explore the properties of 7-hydroxy, why it is so potent, how it compares to other alkaloids present in kratom, and safety considerations for high-potency kratom use.
Understanding 7-Hydroxymitragynine (7-OH) – The Science
Kratom contains more than 40 bioactive alkaloids; however, not all of them are as strong and potent as 7-hydroxymitragynine. 7-hydroxy is found in minor quantities, but it is a highly potent alkaloid that makes up 0.01-0.03% of the total alkaloid content. The effect of 7-hydroxymitragynine is stronger than mitragynine due to its high affinity for opioid receptors.
It is more effective in pain relief as it is a full agonist at μ-opioid receptors, unlike mitragynine, which is a partial opioid agonist.
Chemical Structure & Mechanism
7-OH is a minor alkaloid as compared to mitragynine; however comes in second place. It is typically less than 2% of total alkaloids, but it has a stronger mu-opioid receptor interaction. 7-hydroxy contributes to euphoria, uplift mood effects, sedation, and analgesic pain relief.
Potency Comparison: 7-OH vs. Mitragynine
Mitragynine takes up to 70% of the alkaloid content in kratom. It solely works with receptors in the human body to provide stimulating effects. Even found in smaller amounts, 7-OH is more impactful and potent.
| Alkaloid | Relative Potency | Primary Effects |
| Mitragynine | Baseline (~1x) | Stimulation, mood boost |
| 7-Hydroxymitragynine | 10-30x stronger | Pain relief, sedation |
| Speciociliatine | Mild (~0.5x) | Muscle relaxation |
Which Kratom Strains Are Highest in 7-OH?
All kratom strains have different concentrations of 7-OH.
1. Red Vein Kratom (Best for 7-OH Effects)
- Red Maeng Da is high in 7-OH, which makes it suitable for pain relief.
- Red Bentuangie is good for body aches. It is fermented for a long time, thus has higher 7-OH levels.
- Red Borneo is deeply sedating as it also has a good amount of 7-OH.
2. Enhanced/Extracted Kratom (Artificially Concentrated)
Full spectrum extracts have more 7-hydroxy alkaloids for high effects. Ultra and Gold blends are also enriched with 7-OH by some vendors. Extracts can be exponentially stronger; always dose carefully.
How to Use 7-OH-Rich Kratom Safely
Dosage Guidelines
Dosage is very important in the consumption of 7-hydroxymitragynine, as higher dosages can lead to dependency and addiction. Occurs Naturally provides lab-verified 7OH tablets with full-spectrum alkaloids to provide consistent energy.
These tablets are pure and potent, making them suitable for energy, clarity, and opioid withdrawal support. They also offer other targeted kratom tablets, such as Pseudo red for relief, and a blend of mitragynine and 7-hydroxymitragynine for focus.
Available in: 1, 3, 12, and 30 Count Serving
Safety Tips
You can start with a low dose at a slow pace, which means avoiding consuming it daily. Always stay hydrated to combat side effects and avoid mixing with other beverages such as alcohol or other sedatives.
Conclusion:
7-hydroxy is best for people looking for stronger and potent effects than regular kratom. It is suitable for experienced kratom users, severe pain sufferers, or people looking for fast and potent relief.
However, it is not recommended for first-time kratom users and people with low tolerance to alkaloids. All kratom products require caution and responsible use, as overdose can cause serious side effects.
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