7-Hydroxymitragynine, commonly called 7-OH, is a lesser-known but significant alkaloid derived from the kratom plant, Mitragyna speciosa. This compound has garnered attention for its potential therapeutic effects and its unique properties compared to other alkaloids found in kratom.
This comprehensive guide will explore 7-hydroxymitragynine, how it is formed, its benefits, and the best sources for obtaining it. We will also examine Occurs Naturally as a leading vendor of 7-hydroxymitragynine tablets.
What is 7-Hydroxymitragynine?
7-Hydroxymitragynine, also known as 7-OH mitragynine or just 7-OH, is one of the metabolites of mitragynine, the main alkaloid constituent of kratom leaves. This substance is important in increasing the potency of the analgesia exerted by mitragynine by substantially interacting with mu-opioid receptors akin to morphine.
Notably, early findings suggest that 7-OH engages these receptors more effectively than morphine does. In addition to opioid receptors, 7-hydroxymitragynine modulates dopamine, serotonin, and adrenergic receptors.
How 7-hydroxymitragynine is formed?
Converting kratom’s mitragynine to 7-hydroxymitragynine involves a natural biochemical process that typically occurs after ingestion through metabolism.
Chemists can also reproduce this conversion in a laboratory, using cyclic enzymes known as cytochrome P450 (CYP) isoforms to oxidize mitragynine. This process adds a hydroxy group at the 7-position of mitragynine to form 7-OH.
A patent for converting mitragynine to 7-hydroxymitragynine offers an alternative method. This process uses a particular chemical, referred to as [bis(trifluoroacetoxy)iodo]benzene (PIFA), which sounds complex but can be thought of as a powerful reactant.
A catalyst for the transformation is PIFA, which is reacted with two solvents, tetrahydrofuran and water, after which the mixture is purged with argon to maintain stability of the reaction and inhibit secondary reactions.
The product is then treated to isolate the compound and purify it to obtain high-quality 7-hydroxymitragynine after the chemical reaction.
Kratom Alkaloids: 7 Hydroxymitragynine and Mitragynine Explained
The most active alkaloids in kratom are mitragynine and 7-hydroxymitragynine. For every 1 mg of mitragynine, 7-hydroxymitragynine is present in half of that amount in kratom leaves. These two alkaloids help relax the human body.
Mitragynine takes up to 70% of the alkaloid content in kratom. It only interacts with the receptors in the human body to give a stimulating impact.
Hydroxymitragynine is the main alkaloid of the kratom plant and has a crucial role in modulating the activity of mitragynine at opioid receptors, thereby increasing its analgesic effect. Hydroxymitragyne has a higher potency than morphine in managing pain.
In addition to opioid receptors, 7-Hydroxymitragynine may have a greater influence on the dopamine, serotonin, and adrenergic receptors.
The molecular formula of hydroxymitragynine is C23H30N2O5 with a molecular weight of 414.50 g/mol.
Apart from these two primary alkaloids, there are some minor alkaloids too, like Paynantheine, Speciogynine, Ajmalicine, Mitraphylline, and many more.
Let’s learn a little more about these alkaloids.
1. Paynantheine
You can find very little information about this alkaloid on the internet. Paynantheine is another chemical compound that is widely found in kratom leaves. It has more concentration than 7-Hydroxymitragynine, so basically, it is the second-highest alkaloid after mitragynine. However, it is not commonly discussed as it performs little or no activity in the human body.
2. Ajmalicine
Ajmalicine is another alkaloid receptor antagonist that interacts with the human body to help stimulate and regulate various body organs. It was one of the first alkaloids found in kratom in 1970 in Southeast Asia.
3. Mitraphylline
Mitraphylline is the major pentacyclic oxindole alkaloid that has traditionally been used to treat heart diseases, cancer, arthritis, and bone alignment. This alkaloid has more potential, but it is found in less than 1% of kratom.
4. Speciogynine
Speciogynine is also an alkaloid found in kratom that provides active effects in the human body. There is very little to no research on this, but it has the potential for more studies.
Effects of 7-Hydroxymitragynine
7-Hydroxymitragynine effects include various pharmacological actions due to its potent opioid-like properties. Preclinical research and consumer anecdotes have shown that kratom’s 7-OH content reduces pain, enhances mood, and provides sedative effects.
1. Stress Relief:
7-hydroxymitragynine is known for its potent analgesic effects, relieving pain by acting on the mu-opioid receptors. Research findings suggest that 7-OH is approximately 13 times more potent than morphine.
2. Addiction and Withdrawal Risk:
7-hydroxymitragynine, in the case of using kratom leaves and extracts, is likely to have less severe withdrawal symptoms and addiction potential compared with opioids. However, direct and realized chronic use of 7-OH isolate could lead to addiction, tolerance, and withdrawal-related symptoms.
3. Euphoria and Sedation:
At recreational levels, 7-hydroxymitragynine in whole kratom extracts can produce euphoria and sedation.
4. Potential Medical Applications:
7-OH has shown promise in helping individuals wean off opioids, reducing opioid tolerance, and alleviating withdrawal symptoms.
Benefits of 7-Hydroxymitragynine
There are numerous health benefits of 7-Hydroxymitragynine tablets; some of the compelling ones are as follows:
1. Relaxation & Calmness
With the kind of life that we lead nowadays, getting time off to relax and enjoy is sometimes stressful and difficult. One of the common advantages that tablets provide is relaxation. It is vital to give you the perfect moment of tranquility and promote calmness and relaxation to soothe your mind and body.
2. Boosts Energy
Boosting energy is another health benefit that 7-Hydroxymitragynine provides, as these tablets are formulated with natural ingredients that will increase your productivity and boost your energy when you need it the most.
3. Enhances Focus & Mental Clarity
Getting distracted is one of the easiest things in this busy world. But that’s where 7-Hydroxymitragynine can help. 7-Hydroxymitragynine tablets are made from natural ingredients that help boost your mental clarity and help you concentrate with more focus.
That’s not all, the health benefits of 7-Hydroxymitragynine tablets are also very helpful to keep you focused. So you can do your best in your personal or professional work.
Wrapping Up
7-hydroxymitragynine was shown to have good analgesic effects, close to 13 times more potent than morphine. Further, 7-OH present in whole kratom extracts is claimed to contribute to milder withdrawal effects and lower probabilities of dependency.
These spectacular results call for further 7-OH studies. Nonetheless, individual alkaloids may potentially possess even greater dependency characteristics given their intensity and the absence of other alkaloids, such as mitragynine, which could offset the effects.
All in all, 7-hydroxymitragynine tablets give you a natural way to feel better and have more energy. Whether you want to feel more awake, relax, or concentrate better, 7-Hydroxymitragynine ON7 products can help.
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