What Is 7-Hydroxymitragynine (7OH)? A Complete Guide

7-Hydroxymitragynine, commonly called 7-OH, is a lesser-known but significant alkaloid derived from the kratom plant, Mitragyna speciosa. This compound has garnered attention for its potential therapeutic effects and its unique properties compared to other alkaloids found in kratom.

This comprehensive guide will explore 7-hydroxymitragynine, how it is formed, its benefits, and the best sources for obtaining it. We will also examine Occurs Naturally as a leading vendor of 7-hydroxymitragynine tablets.

What is 7-Hydroxymitragynine?

7-Hydroxymitragynine, also known as 7-OH mitragynine or just 7-OH, is one of the metabolites of mitragynine, the main alkaloid constituent of kratom leaves. This substance is important in increasing the potency of the analgesia exerted by mitragynine by substantially interacting with mu-opioid receptors akin to morphine.

Notably, early findings suggest that 7-OH engages these receptors more effectively than morphine does. In addition to opioid receptors, 7-hydroxymitragynine modulates dopamine, serotonin, and adrenergic receptors.

How 7-hydroxymitragynine is formed?

Converting kratom’s mitragynine to 7-hydroxymitragynine involves a natural biochemical process that typically occurs after ingestion through the metabolism.

Chemists can also reproduce this conversion in a laboratory: using cyclic enzymes known as cytochrome P450 (CYP) isoforms to oxidize mitragynine. This process adds a hydroxy group at the 7-position of mitragynine to form 7-OH.

A patent for converting mitragynine to 7-hydroxymitragynine offers an alternative method. This process uses a particular chemical, referred to as [bis(trifluoroacetoxy)iodo]benzene (PIFA), which sounds complex but can be thought of as a powerful reactant.

A catalyst for the transformation is PIFA, which is reacted with two solvents, tetrahydrofuran, and water after which the mixture is purged with argon to maintain stability of the reaction and inhibit secondary reactions.

The product is then treated to isolate the compound and purify it to obtain high-quality 7-hydroxymitragynine after the chemical reaction.

Kratom Alkaloids: 7 Hydroxymitragynine and Mitragynine Explained

The most active alkaloids in kratom are mitragynine and 7-hydroxymitragynine. For every 1 mg of mitragynine, 7-hydroxymitragynine is present in half of that amount in kratom leaves. These two alkaloids help relax the human body.

Mitragynine takes up to 70% of the alkaloid content in kratom. It only interacts with the receptors in the human body to give a stimulating impact.

Hydroxymitragynine is the main alkaloid of the kratom plant and has a crucial role in modulating the activity of mitragynine at opioid receptors thereby increasing its analgesic effect. Hydroxymitragyne has a higher potency than morphine in managing pain.

In addition to opioid receptors, 7-Hydroxymitragynine may have a greater influence on the dopamine, serotonin, and adrenergic receptors.

The molecular formula of hydroxymitragynine is C23H30N2O5 with a molecular weight of 414.50 g/mol.

Apart from these two primary alkaloids, there are some minor alkaloids too like Paynantheine, Speciogynine, Ajmalicine, Mitraphylline, and many more.

Let’s learn a little more about these alkaloids.

1. Paynantheine

You can find very little information about this alkaloid on the internet. Paynantheine is another chemical compound that is widely found in kratom leaves. It has more concentration than 7-Hydroxymitragynine so basically, it is the second-highest alkaloid after mitragynine. However, it is not commonly discussed as it performs less or no activity in the human body.

2. Ajmalicine

Ajmalicine is another alkaloid receptor antagonist that interacts with the human body to help stimulate and regulate various body organs. It was one of the first alkaloids found in kratom in 1970 in Southeast Asia.

3. Mitraphylline

Mitraphylline is the major pentacyclic oxindole alkaloid that has traditionally been used to deal with heart diseases, cancer, arthritis, and bone alignments. This alkaloid has more potential but it is found in less than 1% in kratom.

4. Speciogynine

Speciogynine is also an alkaloid found in kratom that provides active effects in the human body. There is very little to no research on this, but it has the potential for more studies.

Effects of 7-Hydroxymitragynine

7-Hydroxymitragynine effects include various pharmacological actions due to its potent opioid-like properties. Preclinical research and consumer anecdotes have shown that kratom’s 7-OH content reduces pain, enhances mood, and provides sedative effects.

1. Pain Relief:

7-hydroxymitragynine is known for its potent analgesic effects, relieving pain by acting on the mu-opioid receptors. Research findings suggest that 7-OH is approximately 13 times more potent than morphine.

2. Addiction and Withdrawal Risk:

7-hydroxymitragynine, in the case of using kratom leaves and extracts, is likely to have less severe withdrawal symptoms and addiction potential compared with opioids. However, direct and realized chronic use of 7-OH isolate could lead to addiction, tolerance, and withdrawal-related symptoms.

3. Euphoria and Sedation:

At recreational levels, 7-hydroxymitragynine in whole kratom extracts can produce euphoria and sedation.

4. Potential Medical Applications:

7-OH has shown promise in helping individuals wean off opioids, reducing opioid tolerance, and alleviating withdrawal symptoms.

Benefits of 7-Hydroxymitragynine

There are numerous health benefits of 7-Hydroxymitragynine tablets, some of the compelling ones are as follows:

1. Relaxation & Calmness

With the kind of life that we lead nowadays, getting time off to relax and enjoy is sometimes stressful and difficult. One of the common advantages that tablets provide is relaxation. It is vital for giving you the perfect moment of tranquility and promoting calmness and relaxation to soothe your mind and body.

The best 7-Hydroxymitragynine tablet you can buy for relaxation is the Red Relief ON7.

2. Boosts Energy

Boosting energy is another health benefit that 7-Hydroxymitragynine provides as these tablets are formulated with natural ingredients that will increase your productivity and boost your energy when you need it the most.

The best 7-Hydroxymitragynine tablet for energy is the Green Energy ON7.

3. Enhances Focus & Mental Clarity

Getting distracted is one of the easiest things in this busy world. But that’s where 7-Hydroxymitragynine can help. 7-Hydroxymitragynine tablets are made from natural ingredients that help boost your mental clarity and help you concentrate with more focus.

That’s not all, the health benefits of 7-Hydroxymitragynine tablets are also very helpful to keep you focused. So you can do your best in your personal or professional work.

The best 7-Hydroxymitragynine tablet you can buy to enhance your focus is the Blue Focus ON7.

Occurs Naturally – The Best Place To Buy 7-Hydroxymitragynine Products Online

Finding a trusted and reliable source to buy 7-Hydroxymitragynine tablets online can be quite daunting and stressful. But don’t worry. You’ve finally found the best company to buy 7-Hydroxymitragynine products online from.

Occurs Naturally is committed to providing genuine and high-quality 7-Hydroxymitragynine products with the ease of ordering online and getting delivered to your doorstep.

Top 7-Hydroxymitragynine Tablets

The most effective and authentic 7-Hydroxymitragynine products you can buy are as follows:

1. Relief Red ON7

Whether you are looking to release your stress after a long tiring day or simply alleviate everyday tension, the Relief Red ON7 is the perfect kratom for you. It has high levels of 7-hydroxymitragynine (7-OH), a potent alkaloid known for its relaxing properties.

Benefits Of Relief Red ON7

Promotes peace and calmness
Soothe your mind and body
Help you stay relaxed in times of stress

2. Focus Blue ON7

Recommended products

The best 7-Hydroxymitragynine tablet for focus that stands out in the market when it comes to its effectiveness, and quality is the Focus Blue ON7. This kratom tablet is ideal and a top choice for you if you’re seeking to improve your concentration level and attentiveness. It will help you stay alert and focused for a longer period.

Benefits Of Focus Blue ON7

It will enhance your concentration
Keep you alert and attentive
Improve your mental sharpness

3. Energy Green ON7

Energy Green ON7 tablets are specially formulated to help boost your energy on the most demanding days. Whether you’re looking to tackle your busy schedule, hit the gym, or want to increase your productivity, Energy Green On7 is the perfect solution for you.

Benefits Of Energy Green ON7

Boost your energy
Help you increase your productivity
Enhance your physical performance

Wrapping Up

7-hydroxymitragynine was shown to have good analgesic effects, close to 13 times more potent than morphine. Further, 7-OH present in whole kratom extracts is claimed to contribute to milder withdrawal effects and lower probabilities of dependency.

These spectacular results call for further 7-OH studies. Nonetheless, individual alkaloids may potentially possess even greater dependency characteristics given their intensity and the absence of other alkaloids, such as mitragynine, which could offset the effects.

All in all, 7-hydroxymitragynine tablets give you a natural way to feel better and have more energy. Whether you want to feel more awake, relax, or concentrate better, 7-Hydroxymitragynine ON7 products can help.

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